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BOSTON -- Another strong showing from Jon Lester and a few timely two-out hits led the Boston Red Sox to a much-needed win. Lester worked into the eighth inning and David Ortiz hit a two-run homer as Boston pulled out a 5-2 victory over the Cleveland Indians on Thursday night. Brock Holt hit a two-out, two-run double and Daniel Nava had three hits as the Red Sox won for just the third time in their last 10 games, a dismal stretch that began with a three-game sweep by the Indians last week. "At this point it doesnt matter how many outs there are," Boston manager John Farrell said. "RBIs, runs scored, whether its no outs, two outs, it was just good to get a little breathing room tonight." Lester appreciated it, too. Coming off his shortest start of the season, Lester (7-7) allowed two runs -- one earned -- on eight hits and a walk with four strikeouts in 7 2-3 innings. "Long at-bats, grinding out (Josh) Tomlin all night. David, obviously there in the fourth, big swing puts us up three," said Lester, who won for the third time in four starts. "Unfortunately I go out there and give two right back. But the guys did a good job continuing to battle and put up some runs for me." Koji Uehara pitched a perfect ninth for his 14th save. Jason Kipnis had a two-run single for Cleveland, which has lost three straight games after winning nine of its previous 10. Lester faced one batter over the minimum through four innings and allowed just three singles through five, but let Michael Bourn reach safely to start the sixth when he dropped Mike Napolis throw to first. After a double by Michael Brantley, Kipnis cut the deficit to 3-2 with a sharp single that scooted underneath second baseman Dustin Pedroia. But Boston answered in the bottom half, getting the key hits it has lacked so far this season. Tomlin recorded the first two outs before surrendering a triple to Jonathan Herrera. After reliever Nick Hagadone walked Jackie Bradley Jr., Holt delivered a double to left, scoring both runners and restoring the three-run cushion. "Were hitting the ball hard. We were able to get some two-out hits today," said Holt, who has a hit in 11 of his last 12 games. Bradley Jr. then helped protect the lead in the top of the seventh with a spectacular inning-ending double play, making a leaping catch in front of the Green Monster before firing to first in time to double-up Mike Aviles. "Unbelievable play," Lester said. "I dont know if you can throw the ball further in that outfield. That was huge for me." Boston took the lead in the second on Grady Sizemores RBI double and Ortiz made it 3-0 in the fifth with his 15th homer of the year, a shot to straightaway centre off Tomlin. "Early on it was much of the same," Farrell said of stranding baserunners. "We get into a bases-loaded, nobody out situation (in the second) and hit into some tough luck. "David breaks through for us, as weve witnessed many times. Tomlin (4-3) allowed four runs -- three earned -- on nine hits over 5 2/3 innings, striking out three and walking two. "One of those games I tried to battle through," Tomlin said. "Made a bad pitch to Ortiz. He made me pay for it. Changed the course of the game after that." NOTES: A moment of silence was held before the game for former Red Sox manager Don Zimmer, who died June 4. ... Cleveland 3B Lonnie Chisenhall, a left-handed batter, was not in the lineup despite hitting .393 with seven homers and 32 RBIs in 53 games this season. ... Boston RHP Clay Buchholz, on the 15-day DL due to a hyperextended right knee, is slated to throw five innings in a rehab start for Triple-A Pawtucket on Friday. ... Boston 3B Will Middlebrooks, on the DL with a fractured right index finger, also is scheduled to begin a rehab assignment with Pawtucket on Friday. ... Lester threw eight pitches in the first inning, all for strikes. 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The bumbling Broncos trailed before Manning ever got his hands on the ball because Manny Ramirezs bad snap went for a safety 12 seconds into the game. "It was a crazy start," Manning said, "not the way you expect to start the game." It only got worse for the leagues most prolific point producers who scored 606 of em in the regular season, then dominated the AFC in the playoffs but mustered only Demaryius Thomas 14-yard touchdown catch on the final play of the third quarter at MetLife Stadium. "We couldnt get it to swing, man," left tackle Chris Clark said. "We tried, but they just played better than we did today. It didnt shift. We didnt play Broncos football today. When you got a good thing going, you want to finish it off and we didnt do that today." Dominated in every way, the Broncos (15-4) trudged through the tunnel trailing 22-0 at halftime, then watched Percy Harvin return the second-half kickoff for a TD. "Youve got to play well in this game to win it," said Broncos boss John Elway, who lost Super Bowls by scores of 39-20, 42-10 and 55-10 during his Hall of Fame playing career before winning his last two. Elway returned to rescue his beloved Broncos in 2011 after the franchise foundered and his biggest coup was luring Manning to Denver. Over his two seasons in Colorado, Manning engineered the greatest comeback in NFL history: recovering from neck fusion surgery that weakened his throwing arm to win his fifth MVP award this season when he set records by throwing for 55 TDs and 5,447 yards. But he couldnt match that with the greatest comeeback in Super Bowl history after falling behind 36-0.dddddddddddd "I will tell you this: its hard to get things turned around against a great defence like that," Elway said. "They are a great defence. So, thats why you cant afford to lose the momentum because to try to flip it on a great defence is always hard." This was easily Mannings worst day since trading the blue and white horseshoe of the Indianapolis Colts for the orange-mane mustang of Denver. He was sacked for the first time in the playoffs, threw two interceptions, one of which was returned for a touchdown, lost a fumble and turned it over on downs. The bumbling Broncos finally found the end zone when Thomas made a leaping, twisting grab of Mannings 14-yard pass -- his 100th TD toss for Denver. But he needed a lot more of those to keep up with the efficient Russell Wilson, who didnt commit any turnovers and kept plays alive with his legs and pinpoint passes. "They outplayed us in every facet," tight end Jacob Tamme said. Thomas caught 13 passes for 118 yards but he also had a fumble as Denver was driving in the third quarter. Denver was missing five defensive starters who are on IR that might have made this a fairer fight -- Von Miller, Rahim Moore, Kevin Vickerson, Derek Wolfe and Chris Harris Jr. "We just didnt play like were capable of," Elway said. "Its disappointing. But we had a great year. And hopefully well learn from this. But it started tough and we just couldnt seem to get it going. "Its one of those nights. We had a tremendous year and well hopefully learn from this and were going to go at it again next year." Terrance Knighton, who helped hold Marshawn Lynch to 2.6 yards a carry, was already looking forward to that. "Itll be the 2014 season before you know it," he said. "Itll sting for a little bit tonight and maybe for a few more days but well have to bounce back." ' ' '